March Madness 2025: Will the Blue Bloods Reign in San Antonio Again or Will Chaos Rule?

The 2025 NCAA Tournament is set to tip off in Dayton, Ohio, with the First Four, before culminating in the legendary Alamo City—San Antonio—for the Final Four. If history is any indicator, college basketball’s elite programs have owned this city. Kentucky, UConn, Kansas, and Villanova have all cut down the nets here before, and with the exception of Villanova, they’re all in this year’s bracket. Could we be in for yet another Blue Blood coronation?

Or will this year’s tournament rewrite history? No. 1 Duke, No. 7 UCLA, and No. 11 North Carolina are also in the hunt, and potential matchups like Kentucky vs. UCLA in the Sweet 16 could shake up the entire landscape. The Wildcats must first avoid an early-round disaster, while the Bruins would need to take down No. 2 Tennessee in what could be a thriller.

But let’s talk about what truly makes March Madness legendary: upsets. If SportsLine’s renowned computer model is to be believed, we’re in for some absolute bracket-busting chaos. The algorithm—famous for correctly calling double-digit-seed stunners—has some bold predictions that could ruin your bracket before you even blink.

Bracket-Busting Bombshells: Who’s Going Down Early?

One of the biggest shocks projected? No. 13 Yale toppling No. 4 Texas A&M. The Ivy League powerhouse is riding a red-hot 16-1 streak and boasts one of the best offenses in the country. Meanwhile, A&M—ranked an abysmal 330th in field goal percentage—might be walking straight into a nightmare scenario. Coach Buzz Williams has already fallen victim to a double-digit seed in recent memory (remember Penn State in 2023?). Could history repeat itself?

And then there’s the classic 8-9 matchup: Creighton vs. Louisville. The model says bet on the Bluejays, and here’s why—Creighton’s squad is towering, with four starters at least 6’6”. Louisville? Just one. With seven-footer Ryan Kalkbrenner anchoring the paint and head coach Greg McDermott’s proven March Madness success, this one could get ugly fast.

Cinderella Stories or More of the Same?

The question now: Will March Madness 2025 give us a fairytale or a familiar script? Can a mid-major shock the world, or will San Antonio’s legacy of Blue Blood dominance live on? With a field this loaded, expect heartbreak, buzzer-beaters, and at least one bracket-destroying moment that fans will talk about for years.

Want to know which region will be home to the biggest stunners? Which team is primed for a dream run to the Sweet 16? Check out SportsLine’s full simulation and get the edge before your bracket goes up in flames.